Table 4 The cell types and tissue enrichment of the top 10 human serum sEV miRNAs.

From: Characterization of serum small extracellular vesicles and their small RNA contents across humans, rats, and mice

miRNA_id

he_TPM

hd_TPM

Fold-change

Cell or Tissue enriched

hsa-miR-486-5p

360870.0

325558.5

1.1

mature-erythrocyte

hsa-miR-92a-3p

44958.0

10094.5

4.5

mature-erythrocyte, brain pfc, lung, CD4 + Tcell, monocyte-derived-macrophage

hsa-miR-451a

24460.0

3169.0

7.7

lung, adipose, skin, breast, peripheral bmc

hsa-miR-423-5p

23392.0

28184.0

0.8

testicular germ, pancreatic beta cell, pancreatic islet

hsa-miR-191-5p

8452.0

3218.0

2.6

brain pfc, brain sfg, monocyte-derived-macrophage

hsa-let-7b-5p

5221.5

1320.5

4.0

testicular germ, skin, colon, kidney

hsa-miR-26a-5p

5138.0

633.0

8.1

brain sfg

hsa-miR-10b-5p

3795.5

703.5

5.4

adipose, skin, kidney, colon

hsa-miR-10a-5p

2990.0

465.5

6.4

lung, colon, skin, adipose

hsa-miR-125b-5p

2983.5

986.0

3.0

prostate, ventricular-myocardium, lung, primary fibroblast, gastric

  1. Note: brain pfc, brain prefrontal cortex; brain sfg, brain superior frontal gyrus; peripheral bmc, peripheral blood mononuclear cells.; h, human; sEV, small extracellular vesicle; e, serum small extracellular vesicle; d, small extracellular vesicle-depleted serum; TPM, transcripts per million reads. The TPM values provided here are the average of two biological replicates.