Table 1 Differentially expressed targeted metabolites from the EC of aged male APOE4/4 vs. APOE3/3 mice.
Metabolite | Regulation in E4/4 | Fold Change | p-value | FDR | Detection Mode | CAS Number |
|---|---|---|---|---|---|---|
Fatty Acids | ||||||
gamma-Linolenic Acid | down | 1.31 | 1.19E-03 | 0.093 | positive | 506-26-3 |
Myristic Acid | down | 3.92 | 0.004 | 0.118 | positive | 544-63-8 |
Docosahexaenoic Acid | up | 1.36 | 0.011 | 0.154 | positive | 6217-54-5 |
Stearic Acid | down | 1.69 | 0.011 | 0.154 | positive | 57-11-4 |
12-Hydroxydodecanoic Acid | down | 1.36 | 0.021 | 0.213 | positive | 505-95-3 |
Arachidic Acid | down | 1.40 | 0.037 | 0.230 | negative | 506-30-9 |
Palmitic Acid | down | 1.32 | 0.049 | 0.243 | negative | 57-10-3 |
Oligosaccharides | ||||||
trisaccharide | up | 1.99 | 0.001 | 0.049 | negative | 512-69-6 |
tetrasaccharide | up | 2.24 | 0.015 | 0.169 | negative | 10094-58-3 |
disaccharide | up | 2.20 | 0.015 | 0.169 | negative | 63-42-3 |
Vitamin and Vitamin Derivatives | ||||||
Phylloquinone | up | 1.47 | 0.003 | 0.102 | positive | 84-80-0 |
Tocopherol | up | 2.74 | 0.005 | 0.123 | negative | 59-02-9 |
Dehydroascorbic acid | up | 1.76 | 0.008 | 0.134 | positive | 490-83-5 |
Energy-Related Metabolites | ||||||
Inosine 5′-monophosphate (IMP) | up | 2.26 | 0.003 | 0.0720 | negative | 131-99-7 |
D-Fructose 6-phosphate | up | 1.10 | 0.011 | 0.169 | negative | 643-13-0 |
Succinoadenosine | up | 1.47 | 0.011 | 0.169 | negative | 4542-23-8 |
Carnitine | up | 1.27 | 0.021 | 0.213 | positive | 541-15-1 |
Citric Acid/Isocitric Acid | up | 1.24 | 0.028 | 0.230 | negative | 77-92-9/1637-73-6 |
Malic Acid | up | 1.16 | 0.037 | 0.230 | negative | 97-67-6 |
ATP | up | 1.24 | 0.049 | 0.243 | negative | 56-65-5 |
Cholesterol Metabolites | ||||||
Lanosterol | up | 2.27 | 0.015 | 0.169 | negative | 79-63-0 |
Cholesteryl Acetate | up | 2.29 | 0.015 | 0.169 | negative | 604-35-3 |
Amino Acids | ||||||
Leucine | up | 1.26 | 0.015 | 0.169 | negative | 61-90-5 |
Proline | up | 1.12 | 0.037 | 0.230 | negative | 147-85-3 |
Glycine | up | 1.10 | 0.037 | 0.230 | negative | 56-40-6 |
Tryptophan Metabolites | ||||||
Quinaldic Acid | up | 1.68 | 0.001 | 0.049 | negative | 93-10-7 |
Kynurenine | up | 2.49 | 0.015 | 0.169 | negative | 2922-83-0 |
Kynurenic Acid | up | 1.32 | 0.049 | 0.243 | negative | 492-27-3 |
Cysteine and Methionine Metabolites | ||||||
S-Adenosylhomocysteine | up | 1.15 | 0.021 | 0.213 | positive | 979-92-0 |
Histidine Metabolism | ||||||
Carnosine | up | 1.31 | 0.037 | 0.230 | negative | 305-84-0 |
Arginine and Proline Metabolites | ||||||
4-Oxoproline | up | 1.30 | 0.003 | 0.102 | positive | 4347-18-6 |
Tyrosine Metabolites | ||||||
Vanylglycol (MHPG) | up | 1.64 | 0.011 | 0.169 | negative | 67423-45-4 |
Tyramine | up | 1.06 | 0.028 | 0.216 | positive | 51-67-2 |
Thymidine | down | 1.49 | 0.028 | 0.216 | positive | 50-89-5 |
Uracil | down | 1.38 | 0.049 | 0.243 | negative | 66-22-8 |
Purine Metabolism | ||||||
GMP | up | 1.14 | 0.028 | 0.230 | negative | 85-32-5 |
Miscellaneous | ||||||
Hydroxybutyric acid | up | 1.35 | 0.002 | 0.055 | negative | 5094-24-6 |
Methylglutarylcarnitine | up | 2.42 | 0.005 | 0.134 | positive | 102673-95-0 |
Trimethylamine N-oxide | up | 2.65 | 0.021 | 0.213 | positive | 1184-78-7 |
2-Hydroxypyridine | up | 1.36 | 0.037 | 0.275 | positive | 142-08-5 |
N-Acetylneuraminic Acid | up | 1.23 | 0.037 | 0.230 | negative | 131-48-6 |
