Table 3 GO biological processes observed in the PIUMet analysis of differentially expressed untargeted metabolites from the EC of aged male APOE4/4 vs. APOE3/3 mice.

From: APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

GO Term

Enrichment

p-value

FDR

carboxylic acid transport

12.35

9.80E-20

1.43E-16

carboxylic acid transmembrane transport

22.34

1.36E-16

1.04E-13

long-chain fatty acid metabolic process

18.08

2.77E-13

1.50E-10

fatty acid metabolic process

7.8

1.45E-11

5.40E-09

indolalkylamine metabolic process

44.68

2.48E-09

6.68E-07

disaccharide metabolic process

63.29

6.92E-09

1.77E-06

IMP metabolic process

48.69

3.47E-08

7.43E-06

steroid metabolic process

6.87

1.78E-07

3.24E-05

maltose metabolic process

126.58

4.81E-07

8.06E-05

kynurenine metabolic process

50.63

7.51E-07

1.18E-04

IMP biosynthetic process

50.63

7.51E-07

1.19E-04

tryptophan catabolic process

50.63

7.51E-07

1.20E-04

'de novo’ IMP biosynthetic process

63.29

9.46E-06

1.13E-03

ketone catabolic process

 

3.90E-05

3.92E-03

dopamine metabolic process

20.25

4.12E-05

4.06E-03

neurotransmitter catabolic process

37.97

5.54E-05

5.25E-03

keratan sulfate catabolic process

31.65

1.00E-04

8.37E-03

vitamin metabolic process

6.38

3.60E-04

2.35E-02

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