Figure 4
The effects of MSE administration to HFD mice on the weight status, fasting blood glucose and fat mass. (A) Body weight changes in HFD mice treated with vehicle or MSE (500 or 1,000 mg/kg/day). (B) Fasting blood glucose level in HFD mice treated with vehicle or MSE (500 or 1,000 mg/kg/day). (C,D) Epididymal fat mass level (C) and subcutaneous fat mass level (D) in HFD mice treated with vehicle or MSE (500 or1,000 mg/kg/day). (E–J) mRNA expression of PGC-1α (E, muscle; H, liver), PPARγ (F, muscle; I, liver) and SREBP1c (G, muscle; J, liver) in HFD mice treated with vehicle or MSE (500 or 1000 mg/kg/day). The blood glucose test was performed on 6- to 10-week-old HFD mice. Data are means ± standard errors; n = 6 mice/group. P values were calculated by Dunnett’s procedure (*P < 0.05, †P < 0.01). MSE, melinjo seed extract; HFD, high-fat-diet; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α; PPARα, peroxisome proliferator-activated receptor α; SREBP1c, sterol regulatory element-binding protein 1c.
