Figure 10 | Scientific Reports

Figure 10

From: RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways

Figure 10

Liver analysis. (A) Protein-protein interaction network generated with STRING from DEGs in the Liver. The network comprises 937 nodes and connected with 2691 edges (p-value of 1.0 e-16). For the rest of the details see Fig. 3 and also high resolution panel A in Supplementary information 2. (B) The graph shows t the results from the pathway enrichment analyses for the DEGs obtained from the liver. The bars depict the negative logarithm of the false discovery rate (FDR). (C) Genes with the highest degree of connectivity obtained from the PPI network with Cytoscape. D.I–IV) Top four modules obtained from the PPI network using Cytoscape’s plugin MCODE (Red nodes: Upregulated in hepta KO mice; Green nodes: Downregulated in heptaKO mice).

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