Figure 4 | Scientific Reports

Figure 4

From: RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways

Figure 4

Heart analysis. (A) Protein-protein interaction (PPI) network generated with STRING from DEGs in the heart. The network is composed of 482 nodes and connected with 754 edges (p-value of 1.0 e-16). The edges might be drawn in seven different colors indicating different type of evidence (Red line - fusion evidence; Green line - neighborhood evidence; Blue line - cooccurrence evidence; Purple line - experimental evidence; Yellow line - textmining evidence; Light blue line - database evidence; Black line - coexpression evidence). See also high resolution panel A in Supplementary information 2. (B) The graph shows the results of the pathway enrichment analyses for the DEGs obtained from the heart. The bars depict the negative logarithm of the false discovery rate (FDR). (C) Genes with the highest degree of connectivity obtained from the PPI network with Cytoscape. D.I–IV) Top modules obtained from the PPI network using Cytoscape’s plugin MCODE (Red nodes: Upregulated in hepta KO mice; Green nodes: Downregulated in heptaKO mice).

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