Figure 7
Kidney analysis. (A) Protein-protein interaction network generated with STRING from DEGs in the kidney. The network comprises 430 nodes and connected with 812 edges (p-value of 1.0 e-16). For the rest of the details see Fig. 3 and also high resolution panel A in Supplementary information 2. (B) The graph shows the results from the pathway enrichment analyses for the DEGs obtained from the Kidney. The bars depict the negative logarithm of the false discovery rate (FDR). (C) Genes with the highest degree of connectivity obtained from the PPI network with Cytoscape. D.I–IV) Top four modules obtained from the PPI network using Cytoscape’s plugin MCODE (Red nodes: Upregulated in hepta KO mice; Green nodes: Downregulated in heptaKO mice).
