Figure 4
Multimodal analysis of T cell-based immunotherapy. (a–d) MSOT images of animals from the therapy (a,b) and control group (c, d) at indicated time points. Red colour-coding corresponds to the gradient signal. (e-h) Episcopic fluorescence imaging of the mice presented in (a–d). Accumulation of double labeled T cells was found in tumours of both the therapy (e,f) and the control group (g,h). Within the therapy group, T cells are concentrated around the gradient signal. In the control group, T cells can also be found at the tumour edge and within the tumours. (i,j) Cryo RGB image correlating to the episcopic fluorescence images. In tumours of the therapy group (i,j), cellular decline is visible in central parts of the tumour. Tumours of control animals (k,l) do not present large areas of cell death. Scale bar (MSOT) = 2.5 mm.
