Figure 1

Molecular network identified using the “Interaction search” algorithm in KeyMolnet. Molecules with terms in red, blue, or green text represent proteins with increased, decreased, or both increased and decreased spots, respectively, in samples from DJ-1^−/− mice compared with samples from wild-type mice. The terms in black text represent molecules related to differentially expressed proteins in DJ-1^−/− mice based on the “Interaction search” algorithm in KeyMolnet. The green background represents molecules related to the glycolytic pathway, creatine pathway, and TCA cycle. The pink background represents molecules related to PD. The gray background represents other molecules. Molecules surrounded by an ellipse, triangle, or square represent proteins, protein complexes, or small molecules, respectively. The solid and dotted lines represent active and inactive interactions, respectively, between end molecules. The protein abbreviations represent the gene names summarized in Supplemental Table S1, and those of other molecules correspond to those in KeyMolnet.