Table 3 Enrichment analysis of the differentially expressed metabolites based on pathway-associated metabolite sets.
Metabolite Set | Total | Hits | Statistic | P value | FDR |
|---|---|---|---|---|---|
Propanoate Metabolism | 42.00 | 8.00 | 12.42 | 0.00 | 0.00 |
Tryptophan Metabolism | 60.00 | 8.00 | 10.58 | 0.00 | 0.00 |
Glucose-Alanine Cycle | 13.00 | 5.00 | 12.71 | 0.00 | 0.00 |
Alanine Metabolism | 17.00 | 6.00 | 10.67 | 0.00 | 0.00 |
Urea Cycle | 29.00 | 12.00 | 8.49 | 0.00 | 0.00 |
Lysine Degradation | 30.00 | 5.00 | 11.87 | 0.00 | 0.00 |
Selenoamino Acid Metabolism | 28.00 | 4.00 | 9.71 | 0.00 | 0.01 |
Citric Acid Cycle | 32.00 | 6.00 | 8.70 | 0.00 | 0.02 |
Gluconeogenesis | 35.00 | 7.00 | 7.12 | 0.00 | 0.02 |
Malate-Aspartate Shuttle | 10.00 | 4.00 | 9.27 | 0.00 | 0.03 |
Glutamate Metabolism | 49.00 | 13.00 | 5.61 | 0.00 | 0.03 |
Glycine and Serine Metabolism | 59.00 | 17.00 | 5.96 | 0.00 | 0.03 |
Cysteine Metabolism | 26.00 | 5.00 | 8.09 | 0.00 | 0.03 |
Phenylalanine and Tyrosine Metabolism | 28.00 | 9.00 | 6.08 | 0.01 | 0.03 |
Aspartate Metabolism | 35.00 | 12.00 | 5.86 | 0.01 | 0.04 |
Fatty Acid Biosynthesis | 35.00 | 6.00 | 6.92 | 0.01 | 0.04 |
Fatty Acid Elongation In Mitochondria | 35.00 | 1.00 | 12.17 | 0.01 | 0.06 |
Warburg Effect | 58.00 | 12.00 | 4.82 | 0.01 | 0.06 |
Arginine and Proline Metabolism | 53.00 | 14.00 | 5.02 | 0.02 | 0.06 |
Beta-Alanine Metabolism | 34.00 | 8.00 | 5.60 | 0.02 | 0.06 |
Glutathione Metabolism | 21.00 | 6.00 | 5.99 | 0.02 | 0.06 |
Oxidation of Branched Chain Fatty Acids | 26.00 | 3.00 | 6.88 | 0.02 | 0.06 |
Phytanic Acid Peroxisomal Oxidation | 26.00 | 3.00 | 6.88 | 0.02 | 0.06 |
Ammonia Recycling | 32.00 | 10.00 | 4.95 | 0.02 | 0.06 |
Pyruvaldehyde Degradation | 10.00 | 2.00 | 7.76 | 0.02 | 0.08 |
Valine, Leucine and Isoleucine Degradation | 60.00 | 10.00 | 4.66 | 0.04 | 0.13 |
Carnitine Synthesis | 22.00 | 4.00 | 5.10 | 0.04 | 0.14 |
Fatty acid Metabolism | 43.00 | 2.00 | 6.35 | 0.04 | 0.14 |
Tyrosine Metabolism | 72.00 | 10.00 | 4.03 | 0.04 | 0.14 |
Alpha Linolenic Acid and Linoleic Acid Metabolism | 19.00 | 3.00 | 6.01 | 0.05 | 0.14 |
