Figure 3
From: Hypertonic saline enhances the efficacy of aerosolized gentamicin against Pseudomonas aeruginosa
Dextran and Gentamicin diffusion through the mucin matrix. (a) Mucus matrices of different concentrations laid in the apical compartment of a transwell support were treated with fluorescence labelled-dextran in saline or hypertonic saline. Data shows that hypertonic saline can facilitate the dextran penetration through mucin matrix. Data was collected from three independent experiments. (b) We observed hypertonic saline-gentamicin in both concentrations of mucin reached 100% penetration efficiency at 30 min, compared to gentamicin with saline, which took 60 min in 60 mg mucin and 120 min in 30 mg mucin.
