Figure 2

Morphological analysis of nintedanib-treated mice. (a) Schematic diagram of oxazolone (OXA)-induced animal model. Four groups: untreated controls, OXA only and mice treated with DEX (Dexamethasone) or nintedanib (NIN) one hour after every OXA challenge. (b) Representative photographs of mouse ears from each group on day 0 and 21. (c) Ear thickness was measured every week as indicated. Data are from three independent experiments (n = 15). Data are presented as mean  ±  SEM. Data (Day 21) are analyzed by student t-test. ***p  <  0.005 compared to oxazolone treated. (d) Ear weight was measured at day 21. Data are from three independent experiments (n = 15). Data are presented as mean  ±  SEM and analyzed by one-way ANOVA (****p < 0.001 compared to control, ^##p < 0.01, ^###p < 0.005 compared to oxazolone treated).