Table 1 Univariate and multivariate analysis of factors influencing DSS in 7156 PDAC patients with single-organ metastasis.
Variable | N | 1-year survival rate | 2-year survival rate | 3-year survival rate | Median survival ± SE (M) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
95% CI | p value | HR | 95% CI | p value | |||||||
Single-organ metastasis | 7156 | 16.95% | 5.09% | 1.95% | 4.0 ± 0.08 | 3.84–4.16 | |||||
Gender | female | 3296 | 16.74% | 5.28% | 1.82% | 4.0 ± 0.12 | 3.77–4.23 | >0.05 | |||
male | 3860 | 17.11% | 4.93% | 2.00% | 4.0 ± 0.11 | 3.78–4.22 | |||||
Age | 20–44 years | 190 | 30.51% | 8.49% | NA | 8.0 ± 0.88 | 6.28–9.17 | <0.0001 (20–64 years/65+ years) | 1:1.24 (20–64 years/65+ years) | 1.16–1.36 | <0.0001 |
45–64 years | 3082 | 20.90% | 6.82% | 2.65% | 5.0 ± 0.15 | 4.72–5.28 | |||||
65–74 years | 2231 | 16.84% | 4.36% | NA | 4.0 ± 0.14 | 3.72–4.28 | |||||
75+ years | 1653 | 8.09% | 2.43% | NA | 3.0 ± 0.10 | 2.80–3.20 | |||||
Localization | head | 2829 | 21.26% | 5.24% | 2.27% | 5.0 ± 0.14 | 4.72–5.28 | 0.015 (head/body and tail) | >0.05 | ||
body-tail | 2496 | 19.44% | 4.80% | 1.73% | 4.0 ± 0.14 | 3.72–4.28 | |||||
unknown | 1831 | NA | NA | NA | NA | ||||||
Differentiation | G1, G2 | 790 | 22.27% | 8.15% | 1.82% | 6.0 ± 0.31 | 5.39–6.61 | <0.0001 (G1-2/G3-4) | 1:1.31 (G1-2/G3-4) | 1.17–1.50 | <0.0001 |
G3, G4 | 841 | 13.41% | 3.54% | NA | 4.0 ± 0.20 | 3.61–4.39 | |||||
unknown | 5524 | NA | NA | NA | NA | ||||||
T classification | T4 | 1376 | 17.35% | 4.59% | NA | 5.0 ± 0.11 | 4.79–5.21 | >0.05 | |||
T1-T3 | 4139 | 18.73% | 5.85% | 2.10% | 5.0 ± 0.20 | 4.60–5.40 | |||||
unknown | 1641 | NA | NA | NA | NA | ||||||
Metastatic site | liver | 6252 | 13.87% | 2.99% | 0.6% | 4.0 ± 0.09 | 3.83–4.17 | <0.0001 (others/lung) | 1:0.87 (others/lung) | 0.78–0.97 | 0.013 |
lung | 740 | 19.46% | 4.60% | 0.67% | 6.0 ± 0.32 | 5.37–6.63 | |||||
bone | 147 | 17.00% | NA | NA | 6.0 ± 0.99 | 4.05–7.94 | |||||
brain | 17 | 0 | 0 | 0 | 4.0 ± 0.08 | 2.67–5.33 | |||||
