Figure 5
From: Accelerated identification of serine racemase inhibitor from Centella asiatica
Post-docking interactions between active site residues of serine racemase with madecassic acid and madecassoside. (A) Serine racemase is depicted in cartoon view and madecassic acid in stick model in the binding pocket superposed over malonate with manganese and PLP. (B) Chemical structure of madecasosside (C) Madecassic acid interaction with active site residues of serine racemase where hydrogen bonds are indicated by dashed lines between the atoms involved, while hydrophobic contacts are represented by an arc with spokes radiating towards the ligand atoms they contact. (D–F) shows the interactions of madecassoside with SR. (G) shows the binding pose of both the ligands in the active site of SR.
