Figure 2

Correlation analysis of proteins and metabolites regulated in actively proliferating buffalo mammary epithelial cells (BuMECs). (a) Metscape (Cytoscape Plug-in) analysis generated a complex network comprising input proteins (spherical nodes and dark blue), metabolite (hexagons nodes and neon pink), and reactions (edges). (b) Major metabolic pathways generated. A total of 92 metabolic pathways were associated with the proteins identified in actively proliferating BuMECs. Selected pathways, including de novo fatty acid biosynthesis (I), di-unsaturated fatty acid beta-oxidation (II), glycolysis and gluconeogenesis (III), and pentose phosphate pathway (IV) are shown as subnetworks.