Figure 3 | Scientific Reports

Figure 3

From: In-depth proteome analysis of more than 12,500 proteins in buffalo mammary epithelial cell line identifies protein signatures for active proliferation and lactation

Figure 3

Protein-protein interaction (PPI) network analysis of top 2000 proteins (based on number of peptides identified for each protein) (a) The PPI network was constructed using the Cytoscape where each node represents a protein, and edges represent the interaction between two proteins. The PPI network consisted of 1889 nodes and 8813 edges. (b) Molecular Complex Detection (MCODE) analysis. A total of 138 clusters/modules were extracted from the PPI network using Cytoscape plug-in MCODE. Top three modules with high scores representing Module 1 (I) (MCODE score = 44.364, nodes = 45 and edges = 976) suggested the role of proteins in mitochondrial translation, Module 2 (II) (MCODE score = 38, nodes = 38 and edges = 703) consisted of proteins having role in intra-Golgi and retrograde Golgi-to-ER traffic, and Module 3 (III) (MCODE score = 32.606, nodes = 34 and edges = 538) with proteins mainly involved in class I MHC mediated antigen processing and presentation, and ubiquitin-mediated proteolysis.

Back to article page