Table 3 Multivariate analysis.

From: A new clinical-genomic model to predict 10-year recurrence risk in primary operable breast cancer patients

Parameter

 

DRFI

RFI

DRFS

RFS

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

Age

<40

1.0 (0.5–2.3)

0.9113

1.1 (0.5–2.4)

0.8012

0.8 (0.4–1.5)

0.4521

0.8 (0.4–1.6)

0.5555

40–60

0.8 (0.4–1.7)

0.625

0.9 (0.5–1.8)

0.8634

0.6 (0.4–1.1)

0.1018

0.7 (0.4–1.2)

0.1961

>60

Ref

 

Ref

 

Ref

 

Ref

 

T stage

T1

Ref

 

Ref

 

Ref

 

Ref

 

T2

1.5 (0.8–2.6)

0.1845

1.6 (0.9–2.7)

0.0986

1.4 (0.9–2.3)

0.1629

1.5 (0.9–2.4)

0.0886

T3

2.5 (0.8–7.8)

0.108

2.6 (0.8–7.9)

0.0987

2.1 (0.8–5.8)

0.1348

2.2 (0.8–5.8)

0.1295

N stage

N0

Ref

 

Ref

 

Ref

 

Ref

 

N1

1.6 (0.9–3.0)

0.1237

1.5 (0.8–2.8)

0.1659

1.7 (1.0–2.9)

0.0749

1.6 (0.9–2.7)

0.0989

N2

4.2 (2.1–8.4)

<0.0001

4.1 (2.1–7.9)

<0.0001

3.6 (1.9–6.8)

<0.0001

3.6 (1.9–6.6)

<0.0001

ER/PR status

Both neg.

1.1 (0.6–1.8)

0.8453

1.0 (0.6–1.6)

0.8919

0.7 (0.5–1.2)

0.2329

0.7 (0.5–1.1)

0.16

ER/PR pos.

Ref

 

Ref

 

Ref

 

Ref

 

HER2

Neg.

Ref

 

Ref

 

Ref

 

Ref

 

Pos.

1.0 (0.6–1.7)

0.9571

1.0 (0.6–1.7)

0.8472

0.9 (0.6–1.4)

0.6851

0.9 (0.6–1.5)

0.784

Grade

1

Ref

 

Ref

 

Ref

 

Ref

 

2

1.8 (0.5–6.6)

0.3509

2.2 (0.6–8.0)

0.2149

2.2 (0.8–6.1)

0.1162

2.5 (0.9–6.7)

0.0741

3

1.1 (0.3–4.1)

0.9413

1.5 (0.4–5.6)

0.5862

1.5 (0.5–4.4)

0.444

1.8 (0.6–5.4)

0.2597

LVI

Absent/focal

Ref

 

Ref

 

Ref

 

Ref

 

Prominent

0.7 (0.4–1.2)

0.1818

0.6 (0.4–1.1)

0.1163

0.7 (0.4–1.1)

0.1331

0.6 (0.4–1.1)

0.0857

Surgery

MRM

0.8 (0.4–1.3)

0.337

0.7 (0.4–1.2)

0.1824

1.0 (0.6–1.6)

0.9911

0.9 (0.6–1.4)

0.6674

BCT

Ref

 

Ref

 

Ref

 

Ref

 

Chemo

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

0.5 (0.2–1.4)

0.1864

0.4 (0.1–0.9)

0.0259

0.2 (0.1–0.5)

<0.0001

0.2 (0.1–0.4)

<0.0001

DGM-CM6

Low

Ref

 

Ref

 

Ref

 

Ref

 

High

3.8 (1.6–9.0)

0.0028

3.5 (1.5–8.1)

0.0028

3.2 (1.6–6.3)

0.0009

3.1 (1.6–6.0)

0.0009

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