Figure 7 | Scientific Reports

Figure 7

From: Self-Propelling Targeted Magneto-Nanobots for Deep Tumor Penetration and pH-Responsive Intracellular Drug Delivery

Figure 7The alternative text for this image may have been generated using AI.

(A) Anti-tumor effect of free DOX, CNT-DOX-Fe3O4 and CNT-DOX-Fe3O4-Tf on HCT116 spheroids. Red color shows the fluorescence of DOX under an excitation light with a wavelength of 488 nm. After 72 h exposure, CNT-DOX-Fe3O4-mAb and CNT-DOX-Fe3O4-Tf were efficacious in tumor-spheroid disintegration and were able to induce significant cell death due to enhanced tumor penetration compared to control (untreated tumor). Scale bar for panel represents 100 µm. (B) Deep penetration of CNT-DOX-Fe3O4-Cy5-Tf NPs into the tumor-spheroid core. Confocal microscopy of spheroid reveals co-localization of DOX (red) and Cy5 tagged CNT-DOX-Fe3O4-Cy5-Tf NPs (green) at various depths in the tumor mass suggesting deep penetration of the NPs. The schematic depicts the spheroid thickness (58 µm) and the representative planes shown in the confocal image panel below. Scale bar for panel represents 200 µm.

Back to article page