Figure 2 | Scientific Reports

Figure 2

From: Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model

Figure 2

Juvenile mice born to influenza virus-infected mothers (MIA) and controls (mock) received a single dose of antibiotic or vehicle via oral gavage. Head-twitch behavior (A) and [3H]ketanserin binding assays (B) were performed in adult mice. (A) Effect of injection with the psychedelic 5-HT2AR agonist DOI (0.5 mg/kg), or vehicle, on head-twitch behavior (n = 11 – 19). (B) Radioligand binding with the 5-HT2AR antagonist [3H]ketanserin (10 nM) in mouse frontal cortex membrane preparations (n = 13 – 16). Two-way ANOVA (A) F[1,53] = 27.89, p < 0.001; (B) F[1,54] = 27.07, p < 0.001). Bonferroni’s post hoc test (*p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant). Data show mean ± s.e.m.

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