Figure 12 | Scientific Reports

Figure 12

From: Mucosal delivery of CpG-ODN mimicking bacterial DNA via the intrapulmonary route induces systemic antimicrobial immune responses in neonatal chicks

Figure 12

Histology of lungs 72 hr following IPL saline (A and C) and IPL CpG-ODN (B and D) delivery. At lower magnification (20×), the saline control lung showed slightly less cellularity and more air spaces (A) compared to the CpG-ODN treated lung appearing compact and more cellular (B), although the contrast was less striking 72 hours post treatment. At higher magnification (40× and 100×), the IPL CpG-ODN treated lung (D) contained visibly more lymphocytes (black arrow heads in the insert) and large mononuclear cells resembling monocytes/ macrophages (yellow arrows in the insert) compared to the saline control lungs (C).

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