Table 1 Human (A) and marmoset (B) serum proteins with significant changes during pregnancy.
From: Human PZP and common marmoset A2ML1 as pregnancy related proteins
A. Human | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Categry | No. | Identified Proteins | Pregnancy related proteins (P.R.P) | Protease Inhibitors | UniProt EntryName | UniProt Accession No. | Molecular Weight | Average | ratio | ratio | 1st trimester | 2nd trimester | 3rd trimester | |||||||||||
(P.I.)/Proteases | 1st | 2nd | 3rd | 2nd/1st | p | 3rd/1st | p | H1 | H2 | H3 | H1 | H2 | H3 | H1 | H2 | H3 | ||||||||
1 | 1a | 1 | Pregnancy zone protein | P.R.P. | P.I. | PZP_HUMAN | P20742 | 164 kDa | 2.77 | 11.32 | 7.25 | 4.08 | 0.09 | 2.61 | 0.21 | 8.32 | 0.00 | 0.00 | 25.59 | 4.32 | 4.03 | 21.75 | 0.00 | 0.00 |
2 | Antithrombin-III | P.I. | ANT3_HUMAN | P01008 | 53 kDa | 0.33 | 2.02 | 0.31 | 6.07 | 0.26 | 0.92 | 0.21 | 0.00 | 0.00 | 1.00 | 0.00 | 6.05 | 0.00 | 0.00 | 0.00 | 0.92 | |||
3 | Alpha-1-antichymotrypsin | P.I. | AACT_HUMAN | P01011 | 48 kDa | 0.00 | 2.02 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 6.05 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
4 | Complement C1q subcomponent subunit C | C1QC_HUMAN | P02747 | 26 kDa | 0.00 | 1.15 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 3.46 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
1b | 5 | Serotransferrin | TRFE_HUMAN | P02787 | 77 kDa | 34.12 | 52.12 | 97.23 | 1.53 | 0.17 | 2.85 | 0.14 | 39.51 | 30.93 | 31.92 | 29.68 | 69.20 | 57.49 | 86.98 | 26.89 | 177.83 | |||
6 | Apolipoprotein C-II | APOC2_HUMAN | P02655 | 11 kDa | 10.65 | 12.57 | 23.27 | 1.18 | 0.26 | 2.18 | 0.02 | 5.20 | 12.80 | 13.96 | 7.16 | 10.38 | 20.17 | 20.71 | 28.01 | 21.08 | ||||
7 | Sex hormone-binding globulin | SHBG_HUMAN | P04278 | 44 kDa | 9.52 | 15.90 | 23.72 | 1.67 | 0.01 | 2.49 | 0.02 | 13.52 | 1.07 | 13.96 | 20.47 | 6.05 | 21.18 | 28.99 | 20.17 | 22.00 | ||||
8 | Fibronectin | FINC_HUMAN | P02751 | 263 kDa | 4.82 | 6.10 | 15.77 | 1.27 | 0.40 | 3.27 | 0.03 | 0.00 | 7.47 | 6.98 | 0.00 | 17.30 | 1.01 | 15.53 | 13.45 | 18.33 | ||||
9 | Apolipoprotein L1 | APOL1_HUMAN | O14791 | 44 kDa | 3.09 | 2.55 | 6.96 | 0.83 | 0.12 | 2.25 | 0.08 | 2.08 | 3.20 | 3.99 | 1.02 | 2.60 | 4.03 | 6.21 | 10.08 | 4.58 | ||||
10 | Hemoglobin subunit beta | HBB_HUMAN | P68871 | 16 kDa | 0.36 | 0.97 | 4.40 | 2.73 | 0.24 | 12.37 | 0.17 | 0.00 | 1.07 | 0.00 | 2.05 | 0.86 | 0.00 | 3.11 | 0.00 | 10.08 | ||||
11 | Hemoglobin subunit alpha | HBA_HUMAN | P69905 | 15 kDa | 0.00 | 1.65 | 3.75 | 0.07 | 0.15 | 0.00 | 0.00 | 0.00 | 3.07 | 0.86 | 1.01 | 2.07 | 0.00 | 9.17 | ||||||
12 | Fibulin-1 | FBLN1_HUMAN | P23142 | 77 kDa | 0.00 | 0.91 | 6.95 | 0.11 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 1.73 | 1.01 | 5.18 | 5.60 | 10.08 | ||||||
13 | Complement component C8 alpha chain | CO8A_HUMAN | P07357 | 65 kDa | 0.00 | 0.29 | 1.02 | 0.21 | 0.002 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 1.04 | 1.12 | 0.92 | ||||||
14 | Pregnancy-specific beta-1-glycoprotein 1 | P.R.P. | PSG1_HUMAN | P11464 | 47 kDa | 0.00 | 0.00 | 18.32 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 21.75 | 11.20 | 22.00 | ||||||
15 | Actin, cytoplasmic 1 | ACTB_HUMAN | P60709 | 42 kDa | 0.00 | 0.00 | 7.33 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 22.00 | |||||||
16 | Pregnancy-specific beta-1-glycoprotein 9 | P.R.P. | PSG9_HUMAN | Q00887 | 48 kDa | 0.00 | 0.00 | 4.94 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 9.32 | 0.00 | 5.50 | ||||||
2 | 2a | 17 | Complement C5 | CO5_HUMAN | P01031 | 188 kDa | 10.65 | 4.28 | 5.49 | 0.40 | 0.04 | 0.52 | 0.04 | 8.32 | 10.67 | 12.97 | 1.02 | 1.73 | 10.09 | 5.18 | 6.72 | 4.58 | ||
18 | Complement C1s subcomponent | C1S_HUMAN | P09871 | 77 kDa | 2.76 | 1.01 | 1.77 | 0.37 | 0.10 | 0.64 | 0.13 | 2.08 | 3.20 | 2.99 | 0.00 | 0.00 | 3.03 | 1.04 | 3.36 | 0.92 | ||||
19 | Plasma kallikrein | Protease | KLKB1_HUMAN | P03952 | 71 kDa | 2.35 | 0.96 | 1.29 | 0.41 | 0.20 | 0.55 | 0.22 | 0.00 | 1.07 | 5.98 | 0.00 | 0.86 | 2.02 | 0.00 | 1.12 | 2.75 | |||
20 | Carboxypeptidase N subunit 2 | Protease | CPN2_HUMAN | P22792 | 61 kDa | 1.34 | 0.00 | 1.53 | 0.13 | 1.14 | 0.42 | 1.04 | 0.00 | 2.99 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.58 | ||||
2b | 21 | Ig gamma-1 chain C region | IGHG1_HUMAN | P01857 | 36 kDa | 24.73 | 20.00 | 10.54 | 0.81 | 0.89 | 0.43 | 0.02 | 29.12 | 18.13 | 26.93 | 22.52 | 23.36 | 14.12 | 9.32 | 6.72 | 15.58 | |||
22 | Ig lambda-2 chain C regions | LAC2_HUMAN | P0CG05 | 11 kDa | 9.42 | 11.09 | 4.37 | 1.18 | 0.11 | 0.46 | 0.02 | 7.28 | 16.00 | 4.99 | 7.16 | 19.03 | 7.06 | 4.14 | 8.96 | 0.00 | ||||
23 | Ig kappa chain C region | IGKC_HUMAN | P01834 | 12 kDa | 2.76 | 3.14 | 1.00 | 1.14 | 0.32 | 0.36 | 0.10 | 2.08 | 3.20 | 2.99 | 3.07 | 4.32 | 2.02 | 2.07 | 0.00 | 0.92 | ||||
24 | Histidine-rich glycoprotein | HRG_HUMAN | P04196 | 60 kDa | 1.76 | 0.97 | 0.00 | 0.55 | 0.21 | 0.10 | 2.08 | 3.20 | 0.00 | 2.05 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | |||||
25 | Inter-alpha-trypsin inhibitor heavy chain H3 | P.I. | ITIH3_HUMAN | Q06033 | 100 kDa | 1.40 | 0.68 | 2.59 | 0.49 | 0.21 | 1.84 | 0.28 | 2.08 | 2.13 | 0.00 | 2.05 | 0.00 | 0.00 | 1.04 | 6.72 | 0.00 | |||
26 | Leucine-rich alpha-2-glycoprotein | A2GL_HUMAN | P02750 | 38 kDa | 0.68 | 1.25 | 0.31 | 1.85 | 0.21 | 0.45 | 0.19 | 1.04 | 0.00 | 1.00 | 1.02 | 1.73 | 1.01 | 0.00 | 0.00 | 0.92 | ||||
B. Marmoset | ||||||||||||||||||||||||
Catgory | No. | Identified Proteins | Pregnancy related proteins (P.R.P) | Protease Inhibitors | NCBI GI No. | Accession No. | Molecular Weight | Average | ratio | ratio | 50 days | 100 days | 120 days | |||||||||||
(P.I.)/Proteases | 1st | 2nd | 3rd | 2nd/1st | p | 3rd/1st | p | M1 | M2 | M3 | M1 | M2 | M3 | M1 | M2 | |||||||||
1 | 1a | 1 | Alpha-2-macroglobulin-like | P.R.P. | P.I. | 675677766 | XP_002752342 | 165 kDa | 15.07 | 259.86 | 55.58 | 17.25 | 0.01 | 3.69 | 31.05 | 0.00 | 14.15 | 331.99 | 217.41 | 230.18 | 75.30 | 35.86 | ||
2 | Hemoglobin alpha chain | 122366 | P18972* | 15 kDa | 9.41 | 128.91 | 27.39 | 13.69 | 0.001 | 2.91 | 10.09 | 9.06 | 9.10 | 120.17 | 138.98 | 127.57 | 7.44 | 47.34 | ||||||
3 | Hemoglobin beta chain | 122577 | P18985* | 16 kDa | 4.72 | 74.62 | 20.26 | 15.79 | 0.01 | 4.29 | 2.33 | 6.79 | 5.05 | 72.83 | 58.57 | 92.44 | 4.65 | 35.86 | ||||||
4 | Apolipoprotein A-II | 296229454 | XP_002760286 | 11 kDa | 1.53 | 5.03 | 4.52 | 3.29 | 0.08 | 2.96 | 1.55 | 0.00 | 3.03 | 1.82 | 4.96 | 8.32 | 1.86 | 7.17 | ||||||
5 | Complement component C6 | 390460019 | XP_002745070 | 106 kDa | 0.52 | 4.27 | 1.39 | 8.26 | 0.01 | 2.70 | 1.55 | 0.00 | 0.00 | 6.07 | 3.97 | 2.77 | 2.79 | 0.00 | ||||||
6 | Pigment epithelium-derived factor | 675657740 | XP_008994618 | 47 kDa | 0.97 | 4.63 | 0.93 | 4.76 | 0.25 | 0.96 | 0.78 | 1.13 | 1.01 | 0.00 | 13.90 | 0.00 | 1.86 | 0.00 | ||||||
7 | Immunoglobulin heavy chain variable region | 20502564 | AAM22526** | 15 kDa | 0.52 | 1.99 | 0.46 | 3.85 | 0.13 | 0.90 | 1.55 | 0.00 | 0.00 | 1.21 | 1.99 | 2.77 | 0.93 | 0.00 | ||||||
8 | Zinc-alpha-2-glycoprotein-like | 675642469 | XP_008981062 | 27 kDa | 0.26 | 1.94 | 0.46 | 7.48 | 0.09 | 1.80 | 0.78 | 0.00 | 0.00 | 3.03 | 0.00 | 2.77 | 0.93 | 0.00 | ||||||
9 | Insulin-like growth factor-binding protein complex acid labile subunit | 296219288 | XP_002755809 | 66 kDa | 0.52 | 1.34 | 0.46 | 2.59 | 0.10 | 0.90 | 1.55 | 0.00 | 0.00 | 3.03 | 0.99 | 0.00 | 0.93 | 0.00 | ||||||
10 | Apolipoprotein E | 296234066 | XP_002762273 | 36 kDa | 0.00 | 1.73 | 0.00 | 0.09 | 0.00 | 0.00 | 0.00 | 2.43 | 0.00 | 2.77 | 0.00 | 0.00 | ||||||||
11 | Complement component C8 beta chain | 296208073 | XP_002750920 | 67 kDa | 0.00 | 1.04 | 0.46 | 0.003 | 0.00 | 0.00 | 0.00 | 1.21 | 0.99 | 0.92 | 0.93 | 0.00 | ||||||||
1b | 12 | Plasma serine protease inhibitor | P.I. | 675692410 | XP_002754293 | 50 kDa | 0.93 | 2.25 | 2.87 | 2.41 | 0.22 | 3.08 | 0.78 | 0.00 | 2.02 | 0.00 | 3.97 | 2.77 | 0.00 | 5.74 | ||||
2 | 2a | 13 | Haptoglobin | 296231486 | XP_002761163 | 38 kDa | 71.36 | 0.00 | 10.69 | 0.00 | 0.06 | 0.15 | 87.70 | 19.24 | 107.14 | 0.00 | 0.00 | 0.00 | 21.38 | 0.00 | ||||
2b | 14 | Angiotensinogen | 675750692 | XP_008984059 | 54 kDa | 29.15 | 22.65 | 11.49 | 0.78 | 0.13 | 0.39 | 32.60 | 21.51 | 33.35 | 17.60 | 19.86 | 30.51 | 15.80 | 7.17 | |||||
15 | Alpha-1-acid glycoprotein 1 | 296229919 | XP_002760492 | 25 kDa | 14.29 | 6.26 | 3.29 | 0.44 | 0.05 | 0.23 | 16.30 | 21.51 | 5.05 | 6.07 | 9.93 | 2.77 | 3.72 | 2.87 | ||||||
16 | Complement C4-A | 675651995 | XP_002746418 | 193 kDa | 14.26 | 14.11 | 4.65 | 0.99 | 0.03 | 0.33 | 20.96 | 5.66 | 16.17 | 12.14 | 8.93 | 21.26 | 9.30 | 0.00 | ||||||
17 | Gelsolin | 675639222 | XP_009000537 | 86 kDa | 8.00 | 4.69 | 3.04 | 0.59 | 0.08 | 0.38 | 7.76 | 10.19 | 6.06 | 5.46 | 3.97 | 4.62 | 4.65 | 1.43 | ||||||
18 | Leucine-rich alpha-2-glycoprotein | 296232579 | XP_002761694 | 38 kDa | 7.58 | 5.94 | 0.00 | 0.78 | 0.23 | 5.43 | 1.13 | 16.17 | 1.21 | 12.91 | 3.70 | 0.00 | 0.00 | |||||||
19 | Complement factor H | 675747009 | XP_008983383 | 140 kDa | 5.10 | 4.57 | 1.86 | 0.90 | 0.40 | 0.36 | 6.99 | 2.26 | 6.06 | 7.89 | 3.97 | 1.85 | 3.72 | 0.00 | ||||||
20 | Serum amyloid A-4 protein | 675698869 | XP_009006030 | 15 kDa | 4.63 | 2.46 | 1.39 | 0.53 | 0.12 | 0.30 | 5.43 | 3.40 | 5.05 | 1.82 | 0.00 | 5.55 | 2.79 | 0.00 | ||||||
21 | Plasminogen | Protease | 675655078 | XP_008993588 | 15 kDa | 3.62 | 5.60 | 0.00 | 1.55 | 0.24 | 10.87 | 0.00 | 0.00 | 10.32 | 0.00 | 6.47 | 0.00 | 0.00 | ||||||
22 | Aminopeptidase N | Protease | 675663052 | XP_008996656 | 109 kDa | 1.67 | 0.61 | 0.00 | 0.36 | 0.11 | 3.88 | 1.13 | 0.00 | 1.82 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
23 | Immunoglobulin heavy chain | 20502592 | AAM22540** | 11 kDa | 1.03 | 1.01 | 0.00 | 0.98 | 0.21 | 3.10 | 0.00 | 0.00 | 3.03 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
24 | Complement component C9 | 675646263 | XP_002745089 | 65 kDa | 1.03 | 0.81 | 0.00 | 0.78 | 0.21 | 3.10 | 0.00 | 0.00 | 2.43 | 0.00 | 0.00 | 0.00 | 0.00 | |||||||
