Table 1 Potential therapeutic targets against M. pachydermatis.
From: New Therapeutic Candidates for the Treatment of Malassezia pachydermatis -Associated Infections
EC Number | Abbreviature | Enzyme | Human Match | % Protein similarity |
|---|---|---|---|---|
4.2.1.19 | IGPD | Imidazoleglycerol-phosphate dehydratase | NA | NA |
2.5.1.78 | RIBH | 6,7-Dimethyl-8-ribityllumazine synthase | NA | NA |
2.5.1.9 | RIB | Riboflavin synthase | NA | NA |
2.3.3.14 | HCS | Homocitrate synthase | HMGCL | 14.4 |
1.1.1.3 | HSD | homoserine dehydrogenase | PSB5 | 18.31 |
1.5.1.7; 1.5.1.10 | SDH | Saccharopine dehydrogenase | F8WE53 | 19.71 |
4.2.1.36 | HACN | Homoaconitate hydratase | ACON | 21.36 |
1.1.1.41; 1.1.1.42 | IDH | Isocitrate dehydrogenase | IDH3A | 32.72 |
1.14.13.70 | CYP51A1 | Lanosterol 14 alpha-demethylase | CP51A | 36.48 |
2.7.4.22 | UK | Uridylate kinase | KCY | 40.7 |
1.3.1.- | ERG4/ERG24 | Ergosterol biosynthesis sterol reductase ERG4/ERG24 | LBR | 41.18 |
5.4.2.8 | PMM | Phosphomannomutase | H3BV55 | 51.06 |
6.4.1.1 | PC | Pyruvate carboxylase | PC | 51.43 |
3.6.1.9 | ITPA | Inosine triphosphate pyrophosphatase | ITPA | 52.91 |
6.3.4.5 | AS | Argininosuccinate synthase | ASSY | 55.3 |
