Table 3 MICs (mg/mL) for Malassezia spp. evaluated with L-lysine and L-threonine and values for AB and Flz control (µg/mL).

From: New Therapeutic Candidates for the Treatment of Malassezia pachydermatis -Associated Infections

Strains

MIC L-lysine

MIC L-threonine

MIC to ABa

Microdilution assays

M. pachydermatis CBS 1879b

3.1

>25

0.25

M. pachydermatis C1c

3.1

>25

M. pachydermatis M1c

3.1

>25

M. pachydermatis N1c

3.1

>25

Atypical M. furfurb

3.1

>25

M. sympodialis CBS 7222b

3.1

>25

M. furfur CBS 1878b

1

>25

4

C. krusei ATCC 6258b

2

C. parapsilosis ATCC 22019b

0.25

E-test® method

Strain

Flza

ABa

M. pachydermatis CBS 1879b

48–64

1–2

M. pachydermatis N1c

64–128

3–6

M. pachydermatis M1c

8–16

3–4

M. pachydermatis C1c

4

8

M. furfur CBS 1878b

3–4

>32

M. sympodialis CBS 7222b

0.75–1.5

2

  1. aReference values (µg/mL) amphotericin B (AB) 0.125–8 and fluconazole (Flz) ≤64.
  2. bReference strain.
  3. cCanine isolate.
  4. (—) No tested.
  5. >No inhibition, likely MIC higher.
  6. Microdilution assays were performed in triplicate.
  7. E-test® was done for duplicate and the results are showed among ranks.