Figure 1 | Scientific Reports

Figure 1

From: Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses

Figure 1

Replication kinetics of two oncolytic HSVs (a; NG34-Fluc, b; rQNestin34.5) in mouse and human GBM cells. The day after plating cells, oHSV were added at a MOI of 0.1. Stacked bars show viral yields at 24 (red), 48 (green), and 72 hours (blue). GL261 and CT2A are parental mouse GBM cells, while GL261nectin1 and CT2Anectin1 express the HSV-1 receptor Nectin-1. Human U251, U87ΔEGFR are established human GBM lines which are readily infected by oHSV, while G9, G30, BT333, and BT145 are patient-derived human GBMs grown under GBM stem-like conditions. Error bars shows SD (n = 3).Values on the stacked bars show P-values with Holm-Sidak t-test of CT2A vs CT2Anectin1 at 24, 48 and 72 hours. n.d. = not detected.

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