Figure 4 | Scientific Reports

Figure 4

From: Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses

Figure 4

Tumor volume correlations with tumor- and oHSV-specific CD8+ T-cell infiltrates and oHSV gene expression. MRI and BLI data from three separate experiments were combined to generate scatter dot plots and a linear regression line with the two-sided 95% confidence interval (pink or green shadows). Timing of MRI scans and BLI at various times post-treatment in each experiment are summarized in Fig. S3a. Tumor volumes measured by MRI were tested as follows; FACS analyzed data of (a) GP33 tetramer+ CD8+TCRβ+CD45+live+ cell population, (b) gB498 tetramer+ CD8+TCRβ+CD45+live+ cells population, or BLI-based data of (c) peak signals of Fluc flux or (d) AUC of Fluc across time-points (Fig. S3a). Each plot includes the Pearson’s correlation coefficient (r) and p-value (* < 0.05, **<0.01, *** < 0.001) which are detailed further in Fig. 5.

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