Figure 4 | Scientific Reports

Figure 4

From: The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Figure 4

Relationship between aSyn expression level and pSyn accumulation in primary neurons. Primary neuronal cultures from WT or SNCA−/− embryos were lysed at DIV7 or 14 and the amount of aSyn and TUJ1 quantified by Western blotting. (a) A representative WB is shown. Full length gels are available in Supp. Fig. S10. (b) Quantification of aSyn signal normalized to TUJ1. 6 individual replicates from 3 individual experiments. Means +/− CI95 are shown. Two-way ANOVA was performed, followed by Tukey’s multiple comparisons test. Adjusted p values are shown.

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