Figure 2
From: Translation of mouse model to human gives insights into periodontitis etiology
Regional association plots of the loci DAB2IP/TTLL11 and RNASE2, which suggested association in the meta-analyis of AgP and CP with p < 10−04. (A) DAB2IP/TTLL11. Left panel: The association upstream TTLL11, tagged by rs3763649, was observed in the discovery meta-analysis using AgP and CP cases and controls. Right panel: After exclusion of the CP case-control samples, the associated region was identical to the genetic locus associated with increased quantities of P.G. in humans (Red rectangle = region associated with increased quantities of P.G. in humans. (B) RNASE2. Left panel: The association of the suggested novel susceptibility locus of PD was strongest in the meta-analysis using AgP and CP cases and controls. Right panel: After exclusion of the CP case-control samples, the associated region was less significant, possibly reflecting the reduced statistical power.
