Table 1 Body and liver tissue weights in the taurine-depletion cats after feeding of the experimental diets for 30 weeks.

From: Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats

 

Control group (n = 4)

Depletion group (n = 6)

Weight

Body (kg)

3.1 ± 0.5

3.2 ± 0.4ns

Liver (g)

80.6 ± 13.5

75.7 ± 10.8ns

Blood biochemical parameter

ALT (IU/L)

56.3 ± 14.7

46.7 ± 9.6ns

AST (IU/L)

83.8 ± 9.1

62.7 ± 16.9ns

Glucose (mg/dL)

484.4 ± 55.8

271.6 ± 55.7*

FFA (µEq/L)

385.7 ± 40.5

463.0 ± 225.1ns

Total-Chol (mg/dL)

66.2 ± 7.9

35.3 ± 6.2*

HDL-Chol (mg/dL)

39.7 ± 19.3

10.3 ± 9.5*

TG (mg/dL)

95.4 ± 42.0

69.8 ± 29.0ns

ALP (IU/mL)

12.0 ± 2.9

15.2 ± 4.1ns

C4 (ng/mg)§

5.4 ± 1.6

22.9 ± 6.5*

4βHC (ng/mg)§

28.8 ± 2.1

27.9 ± 1.1ns

25HC (ng/mg)§

6.1 ± 2.9

5.0 ± 2.8ns

Sitosterol (µg/mg)§

7.8 ± 0.7

4.6 ± 0.9*

Phospholipid (mg/dL)

50.6 ± 30.7

49.6 ± 18.2ns

Total-protein (g/dL)

14.6 ± 1.1

14.6 ± 1.1ns

  1. Note: Data are shown as the mean ± SE. *P < 0.05 versus the Control group by unpaired Student’s t-test. §Oxysterols are expressed per Total-Chol (mg). Abbreviations: 4βHC; 4β-hydroxycholesterol, 25HC; 25-hydroxycholesterol, ALP; alkaline phosphatase, ALT; alanine aminotransferase, AST; aspartate aminotransferase, C4; 7α-hydroxy-4-cholesten-3-one, FFA; free fatty acids, ns; no significant difference, TG; triglyceride, Total-Chol; total cholesterol.