Figure 9
From: Time course of bilateral microglial activation in a mouse model of laser-induced glaucoma
P2RY12 expression in contralateral eyes in the photoreceptor outer segment layer (OS), outer plexiform layer (OPL) inner plexiform layer (IPL) and in the nerve fiber-ganglion cell layer (NFL-GCL). Double immunostaining: Iba-1 (A,D,G,J), P2RY12 (B,E,H,K), merge (C,F,I,L). Retinal whole-mounts. In all retinal layers analyzed, most Iba-1+ cells were labelled with anti-P2RY12 antibody at all time points analyzed: 1 d (A–C), 3 d (G–H), 5 d, 8 d and 15 d (D–F,J–L). P2RY12 expression was similar in all instances. This was not the case for dendritic-like cells (arrow in G-I) or perivascular cells, which were P2RY12-.
