Table 2 Association statistics for top sex-specific AD associated variants with pjoint <= 5e-06 and pinter <= 5e-07.
Chro-mo-some | Position (GRCh37) | Rs ID | A1 (effect) | A2 (other) | Effect allele fre-quency (NIMH + NIA) | Effect allele fre-quency (NIMH only) | Effect allele fre-quency (NIA only) | Nearest gene | Qua-lity in TOP-Med | has pseud-ogene on X or Y | Chi-square statistic (FBAT GEE) | P-value (FBAT GEE) | Number of infor-mative families | Z score (sex-spec-ific) | P-value (sex-specific) | Effect allele fre-quency in affected males (NIMH + NIA cohort) | Effect allele fre-quency in affected females (NIMH + NIA cohort) | Effect allele fre-quency in affected males (ADNI cohort) | Effect allele fre-quency in affected females (ADNI cohort) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
10 | 88138165 | rs1008912 | C | T | 0.082 | 0.085 | 0.077 | GRID1 | PASS | FALSE | 44.657 | 2.01E-10 | 108 | −6.608 | 3.97E-11 | 0.133 | 0.059 | 0.046 | 0.048 |
18 | 21048308 | rs181239893 | A | C | 0.006 | 0.009 | 0.001 | RIOK3 | PASS | FALSE | 27.891 | 8.78E-07 | 20 | −5.263 | 1.42E-07 | 0.021 | 0.000 | 0.002 | 0.005 |
8 | 5824905 | rs13259125 | T | C | 0.301 | 0.306 | 0.293 | MCPH1 | PASS | FALSE | 27.662 | 9.84E-07 | 207 | −5.252 | 1.50E-07 | 0.340 | 0.284 | 0.303 | 0.330 |
18 | 45866243 | rs1944572 | T | C | 0.378 | 0.363 | 0.404 | ZBTB7C | PASS | FALSE | 27.45 | 1.09E-06 | 230 | 5.216 | 1.83E-07 | 0.342 | 0.394 | 0.358 | 0.388 |
