Figure 4

The levels of CPF and its metabolite TCP in serum of rats. The rats were administrated orally with CPF, Cd at doses of 1.7 and 0.7 mg/kg BW/day (low dose, L), 5 and 2 mg/kg BW/day (middle dose, M), 15 and 6 mg/kg BW/day (high dose, H), respectively, and their combinations for 90 days. After the 90-day administration, the blood samples were collected and the levels of CPF and its metabolite TCP in serum were measured by using HPLC method. Data were expressed as mean ± SE and the differences among different groups evaluated by ANOVA. Different superscripted letters (a–d) indicate a significant difference among groups (P < 0.05), while the same letters indicate no significant difference among groups (P > 0.05). Abbreviations: BW, body weight; L, low dose; M, middle dose; H, high dose; Cd, cadmium; CPF, chlorpyrifos; TCP, 3,4,5-trichloropyrindinol.