Table 2 The adipokine production by adipocytes differentiated from ADSCs in media with different deuterium content (Control – differentiation medium was made on the base of milliQ water; ddw – differentiation medium was made on the base of deuterium-depleted water; D₂O – differentiation medium was made on the base of deuterated water).

1

Leptin

57,02 ± 12,77

142,56 ± 23,07

17,26 ± 8,53

p_1–2 = 0,0021

p_1–3 = 0,0003

p_2–3 = 0,0001

2

Adiponectin

67,19 ± 15,53

175,12 ± 30,90

33,17 ± 13,77

p_1–2 = 0,0048

p_1–3 = 0,0261

p_2–3 = 0,0008

3

Adipsin

63,66 ± 16,20

35,36 ± 3,76

91,52 ± 16,24

p_1–2 = 0,0228

p_1–3 = 0,0659

p_2–3 = 0,0011

4

Vaspin

39,29 ± 14,07

16,83 ± 2,86

0,92 ± 0,38

p_1–2 = 0,0293

p_1–3 = 0,0034

p_2–3 = 0,0004

5

Chemerin

77,82 ± 11,80

20,12 ± 3,59

16,99 ± 7,28

p_1–2 = 0,0005

p_1–3 = 0,0003

p_2–3 = 0,5052

6

TNF-α

17,89 ± 0,16

12,27 ± 0,77

0,87 ± 0,39

p_1–2 = 0,0001

p_1–3 = 0,0001

p_2–3 = 0,0001

7

IL-6

28,14 ± 5,97

106,60 ± 40,41

11,66 ± 1,98

p_1–2 = 0,0138

p_1–3 = 0,0068

p_2–3 = 0,0008

8

IL-8

46,26 ± 10,89

21,29 ± 6,34

73,49 ± 7,97

p_1–2 = 0,0065

p_1–3 = 0,0093

p_2–3 = 0,0002

9

IL-10

11,15 ± 1,69

5,63 ± 1,78

25,59 ± 8,41

p_1–2 = 0,0191

p_1–3 = 0,0135

p_2–3 = 0,0059

10

MCP-1

30,68 ± 6,77

1,76 ± 0,92

5,51 ± 2,31

p_1–2 = 0,0024

p_1–3 = 0,0008

p_2–3 = 0,0203

11

IP-10

8,12 ± 2,61

1,78 ± 1,51

3,24 ± 2,16

p_1–2 = 0,0446

p_1–3 = 0,0348

p_2–3 = 0,7377