Table 2 Mean fold change (p values) in urinary metabolites, with p < 0.05 at either Visit 1 or Visit 3, in cases of fetal growth restriction compared to controls.

From: Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction

Annotation

 

Visit 1

Visit 3

CAS Registry Number

Fold change

p value

Fold change

p value

1,2-Propanediol

57-55-6

1.95

0.86

3.76

0.01

Kynurenic acid

492-27-3

2.51

0.34

1.39

0.03

n-Heptanoic acid

111-14-8

2.30

0.17

2.79

0.04

Benzoic acid

65-85-0

3.01

<0.01

3.10

0.05

Malonic acid

141-82-2

2.73

0.02

2.43

0.12

2-Ketoleucine/ketoisoleucine

816-66-0

3.03

0.03

2.50

0.26

2-Ketobutyric acid

600-18-0

3.01

0.02

1.88

0.64

2-Methylglutaric acid

617-62-9

4.14

0.03

1.84

0.66

Acetoacetate

541-50-4

5.35

0.04

2.01

0.99

  1. Note: Results presented for metabolites that were significantly (p < 0.05) different in cases compared to controls at one or both study visits as calculated by paired t-test. No associations were significant after FDR adjustment (all q > 0.05). Abbreviations: CAS, Chemical Abstracts Service.
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