Table 1 Classification of genes associated with oral lichen planus.

From: Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets

Functional classification

Genes

Panther GO-Slim Cellular Component:Cytoplasm

TP73, GUCY2C, SOCS3, HSPA1B, AKR1A1, RRM2, GOLPH3, AKR1C3, NOS3, AR, MTRR, PDCD4, MTHFD1, SOCS1, NOS2, PIK3CA, HSPA1L, TP53, NOS1, IRS2, IRS1, MTHFR, MTR, MTHFD2, TP63, (Cytosol, GO:0005829)

Panther GO-Slim Biological Process: MAPK cascade

MAP2K4, KALRN, (JNK cascade, GO:0007254)

Panther GO-Slim Molecular Function: Cytokine receptor binding

GDF15, TGFB1, TGFB3, (Transforming growth factor beta receptor binding, GO:0005160)

Panther Pathway: Inflammation mediated by chemokine and cytokine signaling pathway

CXCL8, CCL11, CCL2, CXCL10, CCL18, CCL5, CCL21, CCL8, CCL22, CCL20, (Chemokine, P00856), CX3CR1, CCR6, CXCR1, CCR7, CCR3, CXCR2, CXCR4, CCR6, CCR1, CCR5, CCR2, (Chemokine receptor, P00854)

  1. Genes significantly associated with oral lichen planus were analyzed in PANTHER. The most specific and relevant subcategories of each group are listed.
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