Figure 10 | Scientific Reports

Figure 10

From: Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α5β1 integrin towards choleresis

Figure 10

Model of α5β1 integrin activation-dependent differential bile acid signaling. Activation of α5β1 integrin with the less efficacious norUDCA results in the formation of FAKY397-P, which leads to c-Src- and PI3-K-dependent Erk-1/2 activation. When α5β1 integrin is activated by the more efficacious TUDC, higher levels of FAKY397-P result, which, in addition, trigger a slower activation of Erk-1/-2 via PI3-K in a c-Src-independent manner7.

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