Table 2 Avocatin B non-compartmental pilot pharmacokinetic analysis. Data are shown as mean ± S.D., N = 3 in each group.

From: Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions

 

Avocadene

Avocadyne

Mean ± S.D.

Mean ± S.D.

Cmax (ng/mL)

1687.90 ± 79.08a

1544.83 ± 216.37a

Tmax (h)

2.00 ± 0.00

2.00 ± 0.00

Kel (h−1)

0.18 ± 0.06a

0.20 ± 0.03a

t1/2 (h)

4.37 ± 1.88a

3.55 ± 0.50a

AUC0_t (ng/ml*h)

9499.48 ± 1243.22a

13032.37 ± 838.88b

AUC0_inf (ng/mL*h)

9071.26 ± 3480.83a

9868.07 ± 2253.16a

  1. Cmax denotes maximum concentration of bioactive in blood; Tmax denotes time at which Cmax occurs; Kel denotes elimination rate constant; t1/2 denotes half-life of bioactive in blood; AUC0_t denotes area-under-the-curve (AUC) from time 0–24 hr; AUC0_inf denotes AUC from time 0 to infinity. Different superscript letters within each row indicates significant differences (P < 0.05) between avocadene and avocadyne, two-tailed Student’s t-test (n = 3).