Figure 1

Chemical structures of triacylglycerol and orlistat. Triacylglycerol structure comprises one glycerol molecule and three fatty acids. (B) Proposed mechanism of orlistat binding. The catalytic triad His349, Asp307, and Ser116 attack orlistat. β-Lactone is hydrolyzed by Ser116 of SAL. The oxygen atom of Ser116 is covalently bound to the carbonyl carbon atom.