Figure 2 | Scientific Reports

Figure 2

From: Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat

Figure 2

Crystal structure of native SAL and the SAL–orlistat complex. (A) Schematic of the SAL structure. α-Helices and β-strands are shown in blue; the lid domain is shown in pink. Fatty acid fragment molecules are shown as sticks. The calcium and zinc ions are shown in orange and green, respectively. (B) Molecular surface depiction of native SAL with positively charged areas shown in blue and negatively charged areas in red. (C) The dimeric form of the SAL complex with orlistat and fatty acids. Each monomer is shown in blue (chain A) and green (chain B), respectively. The lid domain is shown in pink. The orlistat and fatty acid fragment molecules are shown as sticks in magenta and yellow, respectively. All images of molecular structures were prepared using PyMOL (http://www.pymol.org/2).

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