Figure 5 | Scientific Reports

Figure 5

From: Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat

Figure 5

Binding interaction between SAL and orlistat. (A) Overall structure of SAL complex with orlistat and fatty acids. (B) Close-up view. The recognition mode of orlistat at the SAL catalytic site. Two orlistat molecules are overlapped in blue (chain A) and green (chain B) in the stick model. The residues, which indicate orlistat recognitions, are presented as stick models in white. (C) Orlistat-binding regions are highlighted as surface models. (left) Orlistat (blue and green sticks) and SAL complex; (right) Orlistat (blue stick) and the thioesterase domain of human fatty acid synthase complex. Positively charged areas are shown in blue, and negatively charged areas are shown in red.

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