Figure 7
Superimposition of SAL-binding molecules. The orlistat complex (blue and green) and fatty acids fragments in native (magenta) SAL and S116A mutant (yellow). The key residue side chains are shown as sticks, and the protein backbone is shown schematically in light cyan. The catalytic triad residues are shown as sticks (separated structures shown in Supplementary Figure 3). (B) Superimposition of the orlistat complex of SAL (blue) and the phosphonate inhibitor C11 and β-octyl glycoside complex of DGL. SAL (light blue) and DGL (light yellow) overlap. (C) The predicted model of orlistat and DGL (surface model) binding mode. Orlistat molecules are shown as sticks in blue. Positively charged areas are shown in blue, and negatively charged areas are shown in red.
