Figure 4 | Scientific Reports

Figure 4

From: N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists

Figure 4

Effect of N-methylmorphinans 1–4 and their respective N-phenethyl analogues 1a–4a in the mouse rotarod assay. Mice were tested 30 min after s.c. administration of control (saline) or test compounds. Data depicts latencies to fall from the rotarod as the mean percent changes from baseline performance ± SEM (n = 6 mice per group). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. saline group; #P < 0.05 and ###P < 0.001 vs. N-methylmorphinan treated group; one-way ANOVA followed by Tukey’s post hoc test.

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