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Figure 1

From: Serum biomarkers from cell-based assays for AhRL and MIS strongly predicted the future development of diabetes in a large community-based prospective study in Korea

Figure 1

The mean levels of AhRL (TCDDeq, pM) (a) and MIS-ATP (% of CSS-treated control) (b) according to glucose tolerance state at baseline year 2008. (c) Two clusters by K-means clustering in the plot of AhRL vs. ATP. (d) The 3D scatter plot with AhRL, MIS-ATP and MIS-ROS for 2008 diabetes diagnose. (e) Relative risks of diabetes developing within 4 years according to a combination of AhRL and MIS-ATP in the multivariable logistic regression model D (sex, age, smoking, drinking, and exercise, waist circumference, systolic BP, fasting glucose, and triglyceride-adjusted). Non-diabetic subjects (Total = 1,163; male = 503; female = 660) were divided into 4 groups according to their cut-off values of AhRL and MIS-ATP. See Supplementary Table S4 and Fig. S5 for precise values and other models. (f) The incidences of new-onset diabetes per 1,000 people, according to the quartiles of AhRL and MIS-ATP. The incidences were calculated for 1,163 non-diabetic subjects at baseline. There were very few non-diabetic subjects in the lowest quartile (Q1) of AhRL. Quartile ranges for AhRL: Q1 ≤ 1.08; 1.08 < Q2 < 1.94; 1.95 < Q3 < 2.61 pM. Quartile ranges for MIS-ATP: Q1 > 98.7%; 98.7% ≥ Q2 > 91.7%; 91.7% ≥ Q3 > 84.2%; Q4 ≤ 84.2%.

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