Table 3 Mean levels of AhRL and MIS-ATP, classified according to the development of glucose intolerance or diabetes between 2008 and 2012. Gender differences were compared.

From: Serum biomarkers from cell-based assays for AhRL and MIS strongly predicted the future development of diabetes in a large community-based prospective study in Korea

(2008–2012)

Cases (% total)

AhRL (pM, TCDDeq)

p value

MIS-ATP (% of CSS)

p value

NGT, remained with NGT (NGT-NGT)

Total

785 (51.1%)

1.58 ± 0.88

Ref.

95.3 ± 11.5

Ref.

Male

348 (50.7%)

1.64 ± 0.90

Ref.

95.5 ± 11.2

Ref.

Female

437 (51.4%)

1.53 ± 0.86

Ref.

95.1 ± 11.7

Ref.

NGT, progressed to IGT (NGT-IGT)

Total

109 (7.1%)

2.52 ± 1.08

<0.001

89.7 ± 9.9

<0.001

Male

38 (5.5%)

2.45 ± 1.22

<0.001

89.4 ± 11.2

0.002

Female

71 (8.3%)

2.52 ± 1.00

<0.001

89.9 ± 9.3

<0.001

NGT, progressed to diabetes (NGT-DM)

Total

25 (1.6%)

2.69 ± 0.98

<0.001

83.5 ± 10.7

<0.001

Male

13 (1.9%)

2.71 ± 0.90

<0.001

84.8 ± 13.3

0.013

Female

12 (1.4%)

2.67 ± 1.10

<0.001

82.7 ± 7.4

<0.001

IGT reverted to NGT (IGT-NGT)

Total

125 (8.1%)

2.64 ± 1.31

<0.001 [ref]

84.3 ± 10.4

<0.001 [ref]

Male

56 (8.1%)

2.66 ± 1.32

<0.001 [ref]

84.7 ± 11.0

<0.001 [ref]

Female

69 (8.1%)

2.62 ± 1.31

<0.001 [ref]

84.9 ± 9.9

<0.001 [ref]

IGT, remained in IGT (IGT-IGT)

Total

75 (4.9%)

3.59 ± 1.27

<0.001 [<0.001]

81.9 ± 8.3

<0.001 [0.070]

Male

21 (3.1%)

3.51 ± 1.08

<0.001

79.1 ± 7.22

<0.001

Female

54 (6.4%)

3.62 ± 1.35

<0.001

82.9 ± 8.5

<0.001

IGT, progressed to diabetes (IGT-DM)

Total

44 (2.9%)

4.04 ± 1.41

<0.001 [<0.001]

82.3 ± 9.1

<0.001 [<0.265]

Male

27 (3.9%)

4.11 ± 1.30

<0.001 [<0.002]

81.2 ± 8.3

<0.001 [0.111]

Female

17 (2.0%)

3.92 ± 1.61

<0.001

84.1 ± 10.3

<0.001 [0.956]

Remained in diabetes (DM)

Total

374 (24.3%)

4.74 ± 1.85

<0.001

80.4 ± 10.6

<0.001

Male

184 (26.8%)

4.75 ± 1.75

<0.001

80.4 ± 10.8

<0.001

Female

190 (22.4%)

4.73 ± 1.94

<0.001

80.4 ± 10.5

<0.001

  1. AhRL is expressed as 2,3,7,8-tetrachlorodibenzodioxin (TCDD) equivalents (TCDDeq, pM). MIS-ATP is expressed as a percentage of the 10% charcoal-stripped human serum (CSS)-treated control. Values are expressed as mean ± standard deviation. p values were calculated using Students t-test between subjects with NGT that remained with NGT and the other groups. p values in brackets represent comparisons with the IGT, reverted to NGT group.