Figure 2
From: Platelets disrupt vasculogenic mimicry by cancer cells
VM formation by cancer cells in the presence of platelet-sized beads and platelet releasates. In (A); representative images of C32 melanoma and HS-578T breast cancer cells undergoing VM in the presence of buffer control or platelet-sized beads (2 μm) at the indicated ratio (cells:beads). VM structures are expressed as mean ± SEM for n = 3 experiments. *p < 0.05 compared with buffer control, one-way ANOVA. Scale bar is 200 µm, original magnification 40x. In (B); C32 melanoma and breast cancer cells without and with co-culture of α-thrombin-activated platelet releasate at the indicated ratio (cells:supernatant) where the supernatant is the released contents from the respective number of platelets. Data are expressed as mean ± SEM from n = 3 experiments. *p < 0.05, **p < 0.01, one-way ANOVA. Scale bar is 200 µm, original magnification 40x.
