Table 3 Potential biomarkers for IMI exposure discovered by VIP value and ROC analysis.
From: Metabolic disturbance in hippocampus and liver of mice: A primary response to imidacloprid exposure
Biomarkers | VIP | p value | AUC | Sensitivity (%) | Specificity (%) | Youden index | |
|---|---|---|---|---|---|---|---|
Hippocampus | |||||||
Control–Low | Acetylcholine | 2.36 | ** | 0.917 | 83.3 | 100.0 | 0.833 |
sn-Glycerol 3-phosphoethanolamine | 1.18 | * | 0.861 | 83.3 | 83.3 | 0.666 | |
L-Phenylalanine | 1.43 | * | 0.778 | 83.3 | 66.7 | 0.500 | |
Control–High | Acetylcholine | 3.23 | *** | 1.000 | 100.0 | 100.0 | 1.000 |
D-Lyxose | 1.31 | ** | 0.944 | 83.3 | 100.0 | 0.833 | |
Adenine | 1.22 | * | 0.806 | 66.7 | 100.0 | 0.667 | |
GMP | 1.07 | * | 0.861 | 83.3 | 83.3 | 0.666 | |
Liver | |||||||
Control–Low | L-Glutamine | 2.92 | *** | 1.000 | 100.0 | 100.0 | 1.000 |
S-Lactoylglutathione | 2.26 | * | 0.972 | 100.0 | 83.3 | 0.833 | |
Inosine | 7.32 | * | 0.889 | 100.0 | 66.7 | 0.667 | |
AMP | 3.53 | * | 0.889 | 100.0 | 66.7 | 0.667 | |
L-Pyroglutamic acid | 1.50 | * | 0.806 | 100.0 | 66.7 | 0.667 | |
Adenine | 1.25 | * | 0.889 | 83.3 | 83.3 | 0.666 | |
2-Hydroxyadenine | 1.24 | * | 0.833 | 83.3 | 83.3 | 0.666 | |
Control–High | Guanosine | 2.03 | * | 0.889 | 100.0 | 66.7 | 0.667 |
UDP-N-acetylglucosamine | 1.92 | * | 0.806 | 100.0 | 66.7 | 0.667 | |
L-Pyroglutamic acid | 1.73 | * | 0.861 | 100.0 | 66.7 | 0.667 | |
Adenine | 1.57 | * | 0.889 | 100.0 | 66.7 | 0.667 | |
2-Hydroxyadenine | 1.53 | * | 0.889 | 100.0 | 66.7 | 0.667 | |
1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine | 3.11 | * | 0.778 | 83.3 | 83.3 | 0.666 | |
