Table 1 Demographic Clinical Characteristics of the Patients.

From: Concepts of Double Hit and Triple Hit Disease in Multiple Myeloma, Entity and Prognostic Significance

Ā 

No high risk Cytogenetic abnormality (n = 126)

One high Risk Cytogenetic Abnormality (n = 24)

Two High Risk Cytogenetic Abnormalities (n = 7)

Three High Risk Cytogenetic Abnormalities (n = 2)

Total (n = 159)

Demographic and Clinical Characteristics of the Patients

Age (years)

64.5 ± 11.5

65.4 ± 9.4

61.6 ± 9.9

71.0 ± 4.2

64.6 ± 11.1

Gender

(male/female)

60/66

12/12

2/5

2/0

76/83

ISS stage at diagnosis

Ā Ā Ā Ā Ā 

Stage 1

70 (%58.8)

1 (%4.3)

0

0

71(%47.0)

Stage 2

44 (%37.0)

9 (%34.8)

1 (%14.3)

0

53(%35.1)

Stage 3

5 (%4.2)

14 (%60.9)

6 (%85.7)

2 (%100.0)

27(%17.9

First Line Treatment

Ā Ā Ā Ā Ā 

VCD

75 (%59.5)

14(%58.3)

7 (%100.0)

2(%100.0)

98(%61.6)

VD

25 (%19.8)

3 (%12.5)

0

0

28(%17.6)

VTD-PACE

0

3 (%12.5)

0

0

3(%1.9)

Others

26 (%20.7)

4 (%16.7)

0

0

30(%18.9)

Upfront ASCT

39 (%31.0)

7 (%29.2)

1 (%14.3)

0

47(%29.6)

Follow Up Time (moths)

39.3 (5–69)

26.8 (4–54)

6.6 (1–10)

—

Ā 

Overall Survival (months)

57.0 ± 9.6

32.0 ± 25.6

6 ± 4.2

—

50.0 ± 11.0