Figure 3
From: Optimizing clozapine for chemogenetic neuromodulation of somatosensory cortex
Neural response in the brain after CLZ chemogenetic neuromodulation. (a) Representative samples of extracellular recording before (pre) and 30 min. after (post) administration of saline or different doses of CLZ. (b) 2-D raster plot showing that spiking activity over 360 min. depends on the dose of CLZ. Numbers on the Y axis indicate the number of recordings. Scale bar at the right indicates the frequency of neuronal firing (Hz). (Saline (N = 5, n = 12), CLZ 0.01 mg/kg (N = 4, n = 12) CLZ 0.1 mg/kg (N = 5, n = 11) CLZ 1 mg/kg (N = 5, n = 12)) (c) Time-dependent distribution of the average firing rate after administration of saline or different doses of CLZ (2-way ANOVA with Dunn’s multiple comparisons, p < 0.05. *CLZ 0.01 mg/kg vs. saline; #CLZ 0.1 mg/kg vs. saline; †CLZ 1 mg/kg vs. saline). (d) Comparison of firing rates between before and 30 min after CLZ administration. (Student’s t-test, * p < 0.05).
