Figure 1

P07Rik knockout is associated with low circulating insulin levels. (A) Genome browser view of the region encoding P07Rik (mm10). Exons and introns are represented as purple squares and lines, respectively. Circle represents schematic the approach used by the IKMC to generate P07Rik knockout mice. (B) Distribution of non-fasting plasma insulin levels, obtained by the IKMC, in P07Rik mice and control. Data are represented as tukey boxplot showing median, 25th and 75th percentile (C) Genome browser view of the orthologous region in rat (rn6) of mouse P07Rik. Mouse exons and introns are represented as blue squares and line respectively. Arrows indicate the direction of transcription. Total CAGE read counts are represented below gene locus, blue and red represent reads produced from the minus and plus strand, respectively.