Table 1 Baseline demographic, clinical and laboratory parameters stratified by plasma LRG1 level in ESRD patients.

From: Plasma Leucine-Rich α-2-Glycoprotein 1 Predicts Cardiovascular Disease Risk in End-Stage Renal Disease

 

Total

1st Tertile (n = 57)

2nd Tertile (n = 56)

3rd Tertile (n = 56)

p value

LRG1 (μg/mL)

67.7 (15.1)

52.3 (8.0)

67.8 (3.3)

83.4 (11.0)

<0.001*

Age (years)

62.6 (12.2)

61.1 (12.2)

61.6 (12.5)

65.2 (11.5)

0.159

Dialysis vintage (years)

5.3 (4.0)

5.3 (3.8)

5.7 (4.8)

4.9 (3.5)

0.593

Male (%)

42

40

39

46

0.714

Diabetes (%)

41

32

39

54

0.055

WBC (x 1000/μL)

6.3 (2.0)

6.0 (1.8)

6.3 (2.0)

6.7 (2.2)

0.193

Hemoglobin (g/dL)

10.4 (1.2)

10.7 (0.9)

10.5 (1.2)

10 (1.4)

0.013*

Albumin (g/dL)

3.91 (0.42)

3.99 (0.36)

4.00 (0.36)

3.75 (0.50)

0.001*

BUN (mg/dL)

84.3 (19.5)

83.4 (14.5)

89.1 (19.1)

80.5 (23.4)

0.061

Creatinine (mg/dL)

11.7 (2.6)

11.9 (2.4)

12.3 (2.6)

10.8 (2.8)

0.011*

Kt/V (Gotch)

1.46 (0.18)

1.50 (0.18)

1.47 (0.18)

1.42 (0.17)

0.058

nPCR (g/Kg)

1.22 (0.64)

1.29 (0.33)

1.33 (0.38)

1.03 (0.97)

0.099

Total cholesterol (mg/dL)

141.9 (31.5)

140.1(29.9)

142.6 (32.7)

143.0 (32.4)

0.870

Triglyceride (mg/dL)

130.5 (78.1)

130.9 (86.3)

134.3 (71.3)

126.0 (76.8)

0.860

Calcium (mg/dL)

9.6 (0.8)

9.8 (0.9)

9.6 (0.7)

9.4 (0.7)

0.100

Phosphate (mg/dL)

4.9 (1.5)

4.9 (1.6)

5.2 (1.3)

4.6 (1.6)

0.122

Intact PTH (pg/mL)

355.8 (452.1)

290.5 (326.9)

381.0 (487.3)

399.5 (524.6)

0.403

hsCRP (mg/dL)

0.81 (1.46)

0.31 (0.34)

0.53 (0.86)

1.59 (2.16)

<0.0001

IL-6 (pg/mL)

4.79 (3.65)

3.54 (1.61)

3.56 (2.62)

6.62 (4.60)

<0.0001

TNF-α (pg/mL)

6.29 (1.85)

6.43 (1.52)

6.17 (1.93)

6.27 (2.06)

0.88

CAD (%)

22

14

25

27

0.209

CHF (%)

21

19

21

21

0.950

MI (%)

5

2

7

7

0.341

PAOD (%)

7

0

7

13

0.025*

Stroke (%)

4

4

4

5

0.858

CVD (%)

27

16

29

37

0.033*

  1. Demographic and clinic data were compared across among LRG1 tertiles in 169 ESRD patients in the iESRD cohort. Continuous values are expressed as means (SD). nPCR: normalized protein catabolic rate; CAD: coronary artery disease; CHF: congestive heart failure; MI: myocardial infarction; PAOD: peripheral artery occlusive disease; CVD: cardiovascular disease. *p value < 0.05.