Figure 5 | Scientific Reports

Figure 5

From: Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma

Figure 5

Dose response of SF8628 DIPG cell viability. (a) Single agent study of TβRI inhibitors. *p < 0.05, **p < 0.01, ***p < 0.001, n = 4, unpaired t-test of highest dose vs. control. (b) panobinostat and (c) GSK-J4 tested in combination with 10 µM TβRI inhibitors. The relative cell viability of drug(s) treated samples over the DMSO control is shown. When, as in (c) for EW7197, the IC50 value is inconclusive from curve fitting, an apparent upper limit is estimated.

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